Detectable SARS-CoV-2 in blood and anal swab

Detectable SARS-CoV-2 in blood and anal swab. Heneghan C

Published on July 30, 2020

Reference Chen W, Lan Y, Yuan X, et al. Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity. Emerg Microbes Infect. 2020;9(1):469-473. Published 2020 Feb 26. doi:10.1080/22221751.2020.1732837
Study type
Country China
Setting Hospital
Funding Details National Natural Science Foundation of China Grant and by the National Science and Technology Major Project.
Transmission mode Orofecal

Bottom Line

SARs-CoV-2 RNA was readily detected in the blood (6/57 patients) and anal swabs (11/28 patients).

Evidence Summary

11 of 28 cases were anal swab positive, 8 (73%) had severe symptoms. The concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) in one patient

What did they do?

All patients had pneumonia-based diseases but with diversified clinical and analyzed the PCR data of virus detection in different tissues.

Study reliability

They did not collect stool samples from patients and did not pursue viral RNA in the stool.

Clearly defined setting Demographic characteristics described Follow-up length was sufficient Transmission outcomes assessed Main biases are taken into consideration
Yes Partly Yes Yes Yes

What else should I consider?

About the authors

Carl Heneghan

Carl is Professor of EBM & Director of CEBM at the University of Oxford. He is also a GP and tweets @carlheneghan. He has an active interest in discovering the truth behind health research findings