Therapeutics

This theme aims to:

– Improve the quality, reliability, and accessibility of the evidence that underpins medications, devices, operations, and other therapeutic interventions

– Expose and challenging healthcare claims and regulatory failings that prioritise commercial interests over the interests of the public

– Improve understanding, transparency, and reporting of harms from medicines and other therapeutic interventions

Examples of our research in this area are shown below

Salt intake in heart failure patients

Researchers: Mahtani KR, Heneghan CJ, Nunan D, Onakpoya IJ, Roberts NW, Hobbs FDR

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New treatments for atrial fibrillation

This is a pre-publication version of an editorial appearing in the BMJ by Kamal R. Mahtani and Carl Heneghan We

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Neuraminidase Inhibitors

Tom Jefferson – “The neuraminidase inhibitors evidence of harms – in context” This is an Accepted Manuscript of an article

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High costs of orphan medicines

Do the high costs of orphan medicines (medicines used to treat rare diseases) provide good value for money? This is

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Time-dependent bias in oseltamivir

Time-dependent bias is not an issue in randomised studies as treatment (including placebo) is given at the beginning of follow

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Tamiflu Re-analysis

On 30.1.15 the Lancet published a re-analysis of Oseltamavir effects in symptomatic influenza like illness “Oseltamivir treatment for influenza in

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TAMIFLU: BE CAREFUL, LEST BE MISLED

If you wanted to conduct an independent assessment of the clinical usefulness of a drug, would it be wise to

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Oseltamivir results, harms and peer review

I have concerns with the undertaking of the Dobson paper [1] in the Lancet: how the results are presented, the

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Oseltamivir for preventing influenza

Summary of Oseltamivir versus placebo for preventing influenza in adults * Oseltamivir for influenza in adults and children: systematic review

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Scepticism advice on anti flu drugs

This is our response posted on the BMJ to @deb_cohen  article on ‘GPs are told to treat with scepticism advice

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Zanamivir for influenza in adults and children

Abstract Objectives To describe the potential benefits and harms of zanamivir. Design Systematic review of clinical study reports of randomised

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Oseltamivir for influenza in adults and children

Oseltamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments Abstract Objective

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Weight loss supplements: do they work?

An offshoot of the increased prevalence of overweight and obesity is the proliferation in the market of weight loss supplements

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16th edition due to be published in 2015: "Meyler's Side Effects of Drugs

Jeff Aronson has edited the forthcoming 16th edition of “Meylers Side Effects of Drugs: the International Encyclopedia of Adverse Drug Reactions and

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Chlorogenic acids in green coffee & BP

Dozens of dietary supplements are marketed for blood pressure control, but the evidence for effectiveness for most is not established.

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