Clinical course of 18 patients infected with SARS-CoV-2 in Singapore.
The clinical course of 18 patients infected with SARS-CoV-2 in Singapore. Heneghan C.
Published on July 30, 2020
Transmission Dynamics of COVID-19
||Young BE, Ong SWX, Kalimuddin S et al; Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore. JAMA. 2020;323(15):1488-1494. doi:10.1001/jama.2020.3204
||Singapore National Medical Research Council. The polymerase chain reaction work on nonrespiratory clinical samples was partially supported by grant (Combating the Next SARS-or MERS-Like Emerging Infectious Disease Outbreak by Improving Active Surveillance).
SARS-CoV-2 Virus was detectable in the stool of 4 of 8 hospitalized patients.
In 18 hospitalized patients viral shedding from the nasopharynx was prolonged for 7 days or longer among in 15 (83%). Virus was detectable in the stool of 4 of 8 patients (50%) and blood in one of 12 (8%).
What did they do?
Descriptive case series of the first 18 patients diagnosed with polymerase chain reaction (PCR)–confirmed SARS-CoV-2 infection at 4 hospitals in Singapore from January 23rd to February 3rd, 2020; final follow-up date was February 25th 2020.
A small case series of 18 patients. Sample collection in the early phase of the illness was limited; not all patients consented to sample collection, and baseline laboratory data were also not available for all patients. Cycle threshold values are a quantitative measure of viral load, but correlation with clinical progress and transmissibility is not yet known.
|Clearly defined setting
||Demographic characteristics described
||Follow-up length was sufficient
||Transmission outcomes assessed
||Main biases are taken into consideration
What else should I consider?
About the authors