Detection of SARs-CoV-2 in Stool Specimen from an asymptomatic Child
Detection of SARs-CoV-2 in Stool Specimen from an asymptomatic Child
https://www.cebm.net/study/detection-of-sars-cov-2-in-stool-specimen-from-an-asymptomatic-child/
Published on July 30, 2020
Included in
Transmission Dynamics of COVID-19
| Reference |
Tang A, Tong Z‐d, Wang H‐l et al Detection of novel coronavirus by RT‐PCR in stool specimen from asymptomatic child, China. Emerg Infect Dis J 2020; 26: 1337–1339. 10.3201/eid2606.200301 |
| Study type |
|
| Country |
China |
| Setting |
Community |
| Funding Details |
Zhoushan Science And Technology Project); the Zhejiang Scientific and Technological Major Project under the 2020 Emergency; the Zhejiang University special scientific research fund for COVID-19 prevention and control; and the Zhejiang Natural Project on Emergency Research about Community Prevention, Control, Early Warning, and Prediction of the novel coronavirus outbreak. |
| Transmission mode |
Orofecal |
| Exposures |
|
Bottom Line
An asymptomatic child was positive for a coronavirus by reverse transcription PCR in a stool specimen 17 days after the last virus exposure.
Evidence Summary
After additional stool specimens collected on February 2 (ORF1ab Ct 25.6; nucleoprotein gene Ct 25.8) and February 4 (ORF1ab Ct 25.6; nucleoprotein gene Ct 28.3) were positive, the patient received abidol hydrochloride (100 mg 3×/d),
Stool specimens collected on February 7 (ORF1ab Ct 26.3; nucleoprotein gene Ct 27.6), February 8 (ORF1ab Ct 31.4; nucleoprotein gene Ct 30.6), and February 9 (ORF1ab Ct 27.0; nucleoprotein gene Ct 27.0) were positive, but stool specimens collected on February 12 and 14 were negative.
What did they do?
On January 30, 2020, a 10-year-old boy who had no fever or cough but had close contact with 2 confirmed case-patients with laboratory-confirmed COVID-19.
Study reliability
| Clearly defined setting |
Demographic characteristics described |
Follow-up length was sufficient |
Transmission outcomes assessed |
Main biases are taken into consideration |
|
Partly |
Partly |
Yes |
Yes
|
No |
What else should I consider?
About the authors
Carl Heneghan
Carl is Professor of EBM & Director of CEBM at the University of Oxford. He is also a GP and tweets @carlheneghan. He has an active interest in discovering the truth behind health research findings
