Detection of SARs-CoV-2 in Stool Specimen from an asymptomatic Child

Detection of SARs-CoV-2 in Stool Specimen from an asymptomatic Child

https://www.cebm.net/study/detection-of-sars-cov-2-in-stool-specimen-from-an-asymptomatic-child/

Published on July 30, 2020

Reference Tang A, Tong Z‐d, Wang H‐l et al Detection of novel coronavirus by RT‐PCR in stool specimen from asymptomatic child, China. Emerg Infect Dis J 2020; 26: 1337–1339. 10.3201/eid2606.200301
Study type
Country China
Setting Community
Funding Details Zhoushan Science And Technology Project); the Zhejiang Scientific and Technological Major Project under the 2020 Emergency; the Zhejiang University special scientific research fund for COVID-19 prevention and control; and the Zhejiang Natural Project on Emergency Research about Community Prevention, Control, Early Warning, and Prediction of the novel coronavirus outbreak.
Transmission mode Orofecal
Exposures

Bottom Line

An asymptomatic child was positive for a coronavirus by reverse transcription PCR in a stool specimen 17 days after the last virus exposure.

Evidence Summary

After additional stool specimens collected on February 2 (ORF1ab Ct 25.6; nucleoprotein gene Ct 25.8) and February 4 (ORF1ab Ct 25.6; nucleoprotein gene Ct 28.3) were positive, the patient received abidol hydrochloride (100 mg 3×/d), 

Stool specimens collected on February 7 (ORF1ab Ct 26.3; nucleoprotein gene Ct 27.6), February 8 (ORF1ab Ct 31.4; nucleoprotein gene Ct 30.6), and February 9 (ORF1ab Ct 27.0; nucleoprotein gene Ct 27.0) were positive, but stool specimens collected on February 12 and 14 were negative.

What did they do?

On January 30, 2020, a 10-year-old boy who had no fever or cough but had close contact with 2 confirmed case-patients with laboratory-confirmed COVID-19.

Study reliability

Clearly defined setting Demographic characteristics described Follow-up length was sufficient Transmission outcomes assessed Main biases are taken into consideration
Partly Partly Yes Yes No

What else should I consider?

About the authors

Carl Heneghan

Carl Heneghan

Carl is Professor of EBM & Director of CEBM at the University of Oxford. He is also a GP and tweets @carlheneghan. He has an active interest in discovering the truth behind health research findings