Five cases of COVID-19 in France
Five cases of COVID-19 in France. Heneghan C
https://www.cebm.net/study/five-cases-of-covid-19-in-france/
Published on July 30, 2020
Included in
Transmission Dynamics of COVID-19
Reference |
Lescure FX, Bouadma L, Nguyen D et al Clinical and virological data of the first cases of COVID‐19 in Europe: a case series. Lancet Infect Dis 2020; 20: 697–706. 10.1016/S1473-3099(20)30200-0 |
Study type |
|
Country |
France |
Setting |
Hospital |
Funding Details |
REACTing (Research & Action Emerging Infectious Diseases), INSERM, Paris, France |
Transmission mode |
Orofecal |
Exposures |
|
Bottom Line
SARs-CoV-2 viral RNA was detected in the stools of two women out of the case series of five patients
Evidence Summary
Two women diagnosed within a day of exhibiting symptoms, with high nasopharyngeal titres of SARS-CoV-2 within the first 24 h of the illness onset (5·2 and 7·4 log10 copies per 1000 cells, respectively) had viral RNA detection in stools
What did they do?
Undertook a case series of five patients admitted to Bichat-Claude Bernard University Hospital (Paris, France) and Pellegrin University Hospital (Bordeaux, France) and diagnosed with COVID-19 by semi-quantitative RT-PCR on nasopharyngeal swabs. The first patient was diagnosed with the disease on Jan 24, 2020.
Nasopharyngeal, blood, urine, and stool samples were obtained once daily for 3 days from hospital admission, and once every 2 or 3 days until patient discharge.
Study reliability
Clearly defined setting |
Demographic characteristics described |
Follow-up length was sufficient |
Transmission outcomes assessed |
Main biases are taken into consideration |
Yes |
Yes |
Yes |
Yes
|
No |
What else should I consider?
About the authors
Carl Heneghan
Carl is Professor of EBM & Director of CEBM at the University of Oxford. He is also a GP and tweets @carlheneghan. He has an active interest in discovering the truth behind health research findings