Isolation of SARs-CoV-2 from stool specimen of a confirmed case of COVID-19.
Isolation of SARs-CoV-2 from a stool specimen of a confirmed case of COVID-19. Jefferson T, Heneghan C.
Published on July 15, 2020
Transmission Dynamics of COVID-19
||Zhang Y, Cao C, Shuangli Z et al. Isolation of 2019-nCoV from a Stool Specimen of a Laboratory-Confirmed Case of the Coronavirus Disease 2019 (COVID-19). China CDC Weekly. 2020;2(8):123-4.
||National Key Technology R&D Programs of China
Live virus has been isolated from the stools of one severe pneumonia case, pointing to a possible oro-fecal spread.
Live virus in the stools of a Covid-19 patient may mean that in addition to close contact and contact with respiratory secretions of patients, the virus can also be transmitted through the potential fecal-oral route. Potentially this may mean that stool samples may contaminate hands, food and water
What did they do?
Report of an isolation from a stool specimen of a laboratory-confirmed COVID-19 severe pneumonia case. The onset was 16th January 2020; the sample was taken on 1st February 2020 (15 day interval).
A single finding needs replication. Unclear and sparse clinical details.
|Clearly defined setting
||Demographic characteristics described
||Follow-up length was sufficient
||Transmission outcomes assessed
||Main biases are taken into consideration
What else should I consider?
This is a case report which needs confirmation.
About the authors
Carl is Professor of EBM & Director of CEBM at the University of Oxford. He is also a GP and tweets @carlheneghan. He has an active interest in discovering the truth behind health research findings
Tom Jefferson, epidemiologist.