Prolonged presence of SARS‐CoV‐2 in pediatric patients

 Prolonged presence of SARS‐CoV‐2 in pediatric patients. Heneghan C.

Published on July 30, 2020

Reference Xing Y, Wei N, Qin W et al Prolonged presence of SARS‐CoV‐2 in feces of pediatric patients during the convalescent phase. medRxiv 2020. 10.1101/2020.03.11.20033159
Study type
Country China
Setting Paediatric Hospital
Funding Details This study was funded by The National Natural Science Foundation of China (NSFC) [Grant number 81770315]; and Distinguished Taishan Scholars (2019).
Transmission mode Orofecal

Bottom Line

Three children showed a prolonged presence of SARS‐CoV‐2 in feces after throat swabs were negative.

Evidence Summary

One case had fecal SARS-CoV-2 turned negative 8 days after throat swabs were negative, another child lagged behind for 20 days. At the time of publication, one child still had positive results for RT-PCR analysis in stools after negative conversion of viral RNA in respiratory samples (over 19 days behind).

What did they do?

From January 17, 2020, to March 6, 2020, three pediatric cases of COVID-19 were reported in Qingdao, Shandong Province, China.

Real-time fluorescence reverse-transcriptase-polymerase-chain reaction (RT-PCR) was performed to detect SARS-CoV-2 RNA in throat swabs and fecal specimens.

Study reliability

Clearly defined setting Demographic characteristics described Follow-up length was sufficient Transmission outcomes assessed Main biases are taken into consideration
Yes Partly Partly Yes Yes

What else should I consider?

About the authors

Carl Heneghan

Carl is Professor of EBM & Director of CEBM at the University of Oxford. He is also a GP and tweets @carlheneghan. He has an active interest in discovering the truth behind health research findings