The first case of COVID-19 in the USA

The first case of COVID-19 in the USA. Heneghan C

Published on July 30, 2020

Reference Holshue ML, DeBolt C, Lindquist S et al First case of 2019 novel coronavirus in the United States. N Engl J Med 2019; 382: 929–936. 10.1056/NEJMoa2001191
Study type
Country USA
Setting Hospital
Funding Details Non Reported
Transmission mode Orofecal

Bottom Line

Stool obtained in a single case report was positive for SARs-CO-V-2 on day 7 of the illness.

Evidence Summary

On January 20th  2020, the CDC confirmed the patient’s nasopharyngeal and oropharyngeal swabs tested positive by rRT-PCR for SARs-CO-V-2. Stool obtained on illness day 7 was also positive (Ct values, 36 to 38).

What did they do?

A Case Report. Specimens for repeat SARs-CO-V-2 testing were collected on illness days 7, 11, and 12 and included nasopharyngeal and oropharyngeal swabs, serum, and urine and stool samples.

Study reliability

Clearly defined setting Demographic characteristics described Follow-up length was sufficient Transmission outcomes assessed Main biases are taken into consideration
Yes Yes Yes Yes No

What else should I consider?

About the authors

Carl Heneghan

Carl is Professor of EBM & Director of CEBM at the University of Oxford. He is also a GP and tweets @carlheneghan. He has an active interest in discovering the truth behind health research findings