The first case of COVID-19 in the USA
The first case of COVID-19 in the USA. Heneghan C
https://www.cebm.net/study/the-first-case-of-covid-19-in-the-usa/
Published on July 30, 2020
Included in
Transmission Dynamics of COVID-19
| Reference |
Holshue ML, DeBolt C, Lindquist S et al First case of 2019 novel coronavirus in the United States. N Engl J Med 2019; 382: 929–936. 10.1056/NEJMoa2001191 |
| Study type |
|
| Country |
USA |
| Setting |
Hospital |
| Funding Details |
Non Reported |
| Transmission mode |
Orofecal |
| Exposures |
|
Bottom Line
Stool obtained in a single case report was positive for SARs-CO-V-2 on day 7 of the illness.
Evidence Summary
On January 20th 2020, the CDC confirmed the patient’s nasopharyngeal and oropharyngeal swabs tested positive by rRT-PCR for SARs-CO-V-2. Stool obtained on illness day 7 was also positive (Ct values, 36 to 38).
What did they do?
A Case Report. Specimens for repeat SARs-CO-V-2 testing were collected on illness days 7, 11, and 12 and included nasopharyngeal and oropharyngeal swabs, serum, and urine and stool samples.
Study reliability
| Clearly defined setting |
Demographic characteristics described |
Follow-up length was sufficient |
Transmission outcomes assessed |
Main biases are taken into consideration |
|
Yes |
Yes |
Yes |
Yes
|
No |
What else should I consider?
About the authors
Carl Heneghan
Carl is Professor of EBM & Director of CEBM at the University of Oxford. He is also a GP and tweets @carlheneghan. He has an active interest in discovering the truth behind health research findings
