SARS-CoV-2 in urine, blood, anal swabs and oropharyngeal swabs samples

SARS-CoV-2 in urine, blood, anal swabs and oropharyngeal swabs samples. Heneghan C.

https://www.cebm.net/study/sars-cov-2-in-urine-blood-anal-swabs-and-oropharyngeal-swabs-samples/

Published on July 30, 2020

Reference Peng L, Liu J, Xu W et al. Novel coronavirus can be detected in urine, blood, anal swabs and oropharyngeal swabs samples. medRxiv 2020.02.21.20026179. doi:10.1101/2020.02.21.20026179
Study type
Country China
Setting Hospital
Funding Details Natural Science Foundation of China, Tackling of key scientific and emergency special program of Sun Yat-sen University and Emergency special program for 2019-nCoV of Guangdong province science and technology project.
Transmission mode Orofecal
Exposures

Bottom Line

Virus was found in urine, blood, anal swabs (n =2) and oropharyngeal swabs of nine patients diagnosed with COVID-19

Evidence Summary

All patients presented with a fever. Other symptoms were cough, sore throat, fatigue and diarrhoea. Two patients had positive anal swabs:

  • Patient 8 had three positive results in blood, anal swab and oropharyngeal swab on the 3rd day after onset. 
  • Patient 9 the viral load was roughly higher in anal swab than oropharyngeal swab 

What did they do?

Samples were collected from nine patients diagnosed with COVID-19. Patients’ demographic data and clinical characteristics were recorded. Urine, blood, anal swabs and oropharyngeal swabs from SARS-CoV-2 RNA level by quantitative real-time polymerase chain reaction (qRT-PCR). 

Study reliability

Clearly defined setting Demographic characteristics described Follow-up length was sufficient Transmission outcomes assessed Main biases are taken into consideration
No Partly Yes Yes No

What else should I consider?

About the authors

Carl Heneghan

Carl Heneghan

Carl is Professor of EBM & Director of CEBM at the University of Oxford. He is also a GP and tweets @carlheneghan. He has an active interest in discovering the truth behind health research findings